We are an academically focused clinical research institution. Focused on cutting-edge, investigator-initiated cancer research, we provide clinical researchers with a high-end, completely scalable (from full-service to tailor-made selection of tasks), independent, and professional platform for planning and conduct of scientifically motivated clinical research. Our mission is to advance scientifically motivated clinical research on cancer and help delivering answers to current and future important clinical questions in this field.
Excellence In Research
The objective for our research activities is clearly set: Facilitate excellent clinical cancer research at international level to improve the treatment and quality of life of patients suffering from cancer.We are not a pharmaceutical company and therefore our real ‘product’ is the gain in scientific knowledge. This is achieved by clinical trials that focus on endpoints relevant to patients such as response rate, survival and quality of life.Read more ...
Translational research is an important component of our study designs. Wherever possible, we collect materials to help researchers gaining a better understanding of pathogenesis and development of cancer. Currently, we are participating in several projects and work with TR initiatives like the German Cancer Consortium (DKTK).
We help our academic partners improving personalized cancer therapy by establishing large networks for molecular profiling. IKF is the home of several networks including:
- PARAGON: Platform for Outcome, Quality of Life and Translational Research on Pancreatic Cancer
Clinical ResearchRead less
Excellence in Research
The objective for our research activities is clearly set: Facilitate excellent clinical cancer research at international level to improve the treatment and quality of life of patients suffering from cancer. We are not a pharmaceutical company and therefore the ‘product’ we offer is the gain in scientific knowledge. This is achieved by clinical trials that focus on endpoints relevant to patients such as response rate, survival and quality of life. Our mission is to design and successfully conduct such studies in close cooperation with our scientific partners. In our work, we emphasize clinical relevance and provide answers to long-standing clinical questions to make sure our studies provide improvements to the everyday life of patients.
To accomplish this, we rely on our extensive and long-standing experience in the field of investigator-initiated trials (IITs), which have been and always will be a focus of our work. Therefore, IKF Klinische Krebsforschung GmbH is often the sponsor of phase I to phase III IITs with internal or external lead investigators who are among the best experts in their fields, worldwide. Some of our studies have changed standards of care around the globe, e.g. for patients suffering from stomach or esophageal cancer. A fact which we remain to be very proud of.
Early Clinical Research
Within the last decades, we accumulated profound expertise in designing and conducting early clinical trials, including first in man studies, specifically on immunotherapeutic agents and targeted therapies. For the conduct of early clinical trials, we partner public research institutes or excellent start-up biotech companies who proved to have promising compounds and mutually develop their drugs until approval or successful out-licensing.
Statistical parameters play an important role to ensure the overall success of a clinical trial. Our statistics team is therefore already involved in the planning of the study ...Read more ...
Full-Service CRORead less
We are unique becauseRead less
We are a high-end completely scalable platform from full-service to tailor-made selection of tasks. These tasks include:
- Study related processes in accordance with AMG (German medicines act) and ICH-GCP
- Project design and development including complex trial designs like studies using multi-modal or interdisciplinary therapy approaches or studies with special forms/routes of study medication administration (drug targeting), budget control and assistance when applying for research funds and grants
- Onsite monitoring (Risk-based)
- Safety: SAE management, SAE second assessment, annual safety report / development safety update report (DSUR), regulatory reporting, etc.
- Medical review and electronic/manual data cleaning
- Excellent medical expertise in the development and design of clinical trial protocols, synopses, patient information, informed consent forms, operating- and process procedure descriptions
- Reporting and Publishing
We have a fully implemented quality management system (QMS) including a quality manual, SOPs, sponsor oversight (vendor qualification and audits)
Our data management focuses on quality control and data integrity of the clinical study database – from database setup to database lock. We provide the specification and development of user-friendly electronic case report forms (eCRFs) based on a well-structured database to ensure high-quality data for statistical analysis.
- Specification, eCRF design
- Randomization support
- Data management plan
- Data validation plan
- CDISC standards
- Query management
- Real-time data reports
- Data validation, eChecks
- Data cleaning
Browser-based EDC system (compliant to regulatory standards, e.g., ICH-GCP, 21 Part 11, GAMP v5)
Statistical parameters play an important role to ensure the overall success of a clinical trial. Our statistics team is therefore already involved in the planning of the study at an early phase and cooperates closely with the data management.
- Statistical considerations of study design
- Sample size calculation
- Statistical analysis plans
- Conduction of statistical analysis
- Interim analyses using adaptive designs
Statistical analysis reports
Multidisciplinary teams: Our colleagues have a background in medecine, pharmacy, human biology, chemistry, epidemiology, bioinformatics, statistics, data management and monitoring (clinical research associates)
Excellent networks: Established network of more than 300 medical institutions and the largest study groups for multicenter studies, Access to the functional units of Northwest Hospital, e.g. endoscopy, intensive care and surgery, Specialized (oncological) phase I unit in cooperation with Northwest Hospital
Industry-in-Clinic Platform: IKF provides well-established access to the routine clinical oncology environment via longterm collaborations with university hospitals and other large hospitals.
Over the span of several years our work has earned us an excellent reputation in the field of oncology studies. But this is not solely a consequence of the groundbreaking scientific results we could achieve in close cooperation with our research partners. We owe our success largely to the extraordinary efforts, smartness, and sense of responsibility among our employees. Our staff is dynamic, multidisciplinary and highly experienced. The background of our employees often comprises a high degree (PhD) in medical or natural sciences. Beside medical professionals, our team comprises biologists, a human biologist, bioinformaticians, data managers, monitors (clinical research associates), a statisticians, chemists, and an epidemiologist. We speak over 10 different languages (including English, French and Italian). Members of our staff aim to form sustainable and long-term professional relationships with our partners. That enables us to meet challenges effectively. Our partners benefit from this approach as well as from the professional expertise, the sound scientific background of our employees and their excellent network and acceptance within the scientific community.
Our cooperating phase I unit at Northwest Hospital in Frankfurt/ University Cancer Center Frankfurt offers up to 12 in- or day patient beds with full access to the intensive and emergency care units. Most patients who are treated in our phase I unit participate in phase I trials, but also phase II or phase III participants may be treated in the phase I unit in case of very complex trial procedures. The phase I unit is part of the University Cancer Center Frankfurt (UCT) and has access to associated biomarker networks like TRON, Stratifyer, the Immunological Research labs and several pathology departments etc.
Four treatment rooms with 3 beds each
A modern multi-purpose room
On site lab for clinical diagnostics and adequate processing of trial materials and specimen
Mobile IT, ultrasound and ECG equipment
Modern standard emergency equipment
In-house emergency care and both medical and surgical intensive care units
24 hours resuscitation team on duty
In-house pharmacy, institutes of radiology and interventional radiology, neuroradiology and pathology, departments for oncology and radiation oncology, central lab, endoscopy and interventional endoscopy
Network, Partners, and Supporters
For the conduct of our phase II and phase III studies, we coordinate a national network of more than 300 medical centers and partner powerful academic research groups such as the German Gastric Group at AIO, FLOT study group, German Cancer Society, the German Rectum Study Group and others.
Concept and Contents
Institut für Klinische Krebsforschung IKF GmbH
am Krankenhaus Nordwest
Steinbacher Hohl 2-26
60488 Frankfurt am Main
Tel.: +49 69 – 76 01 44 20
Fax: +49 69 – 76 01 36 55
Commercial Register: HRB 109651
Register Court: Frankfurt am Main
Registered seat of the company: Frankfurt am Main
Managing Director: Prof. Dr. med. Salah-Eddin Al-Batran
Realization and technical maintenance of the website: Omar Musa
Accountability for content
All rights reserved. Reproduction (full or in parts), commercial distribution and listing in commercial databases requires the prior consent of Institut für Klinische Krebsforschung IKF GmbH, Frankfurt/M.
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The operators of this website have done everything to ensure that this information is both correct and up-to-date but they do not give any explicit or implicit guarantee for the information provided on this webpage. The operators of this website do not take over any responsibility for actions taken on the basis of these information.
Accountability for links
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Institut für Klinische Krebsforschung IKF GmbH explicitly dissociates itself from all contents of the linked pages in this website because these are made accessible by external service providers and Institut für Klinische Krebsforschung IKF GmbH has absolutely no influence on the truthful content of such links. This disclaimer also applies to all links found on the pages.